Shaghayegh Kamian

Shahid Beheshti University of Medical Sciences, Iran

Abstract Title: Effect of timing of surgery and chemotherapy after initial diagnosis for early breast cancer on survival

Biography: Shaghayegh Kamian has completed radiation oncology residency in 2006 from Tehran university of medical sciences. She worked in private hospitals for 6 years. She has worked as an associate professor in department of radiation oncology in Imam Hossein hospital, Shahid Beheshti University of Medical Sciences since 2012. She is the reviewer of international journals. She has studied 3 years of master degree in medical education. She has published more than 30 papers in the international journals.

Research Interest: It is assumed that patients with early breast cancer might benefit from starting adjuvant chemotherapy soon after surgery, and this would have important clinical implications. There are different timelines in studies to introduce best time for starting chemotherapy. Some studies have found that timing less than 21 days had no impact on survival; while others have estimate that initiation of chemotherapy greater than 4 months after diagnosis was associated with poorer overall survival. There are also some researches indicating delay in initial surgery more than 45 days might affect survival. We studied 93 breast cancers in our center and found that time interval of 60 days or longer between biopsy and surgery adversely impact overall survival. It should be noted that the presence of comorbidities and metastasis are likely to reduce overall survival. By the use of neoadjuvant chemotherapy, this issue can be more questionable. The criteria for this approach are defined, but still there are debates in time of surgery in these cases. Although there are studies for indicating the best approach for time of chemotherapy and surgery and effect of that on disease free survival and overall survival, we should treat cases regarding comorbidity and desire of patients. Keywords: Breast neoplasm, Surgery, Chemotherapy, Survival